Light-activated ruthenium complexes photobind DNA and are cytotoxic in the photodynamic therapy window.
نویسندگان
چکیده
Incorporation of biquinoline ligands into Ru(II) polypyridyl complexes produces light-activated systems that eject a ligand and photobind DNA after irradiation with visible and near-IR light. Structural analysis shows that distortion facilitates the photochemistry, and gel shift and cytotoxicity studies prove the compounds act as anti-cancer photodynamic therapy (PDT) agents in the tissue penetrant region.
منابع مشابه
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عنوان ژورنال:
- Chemical communications
دوره 48 77 شماره
صفحات -
تاریخ انتشار 2012